Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked...
Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent
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Publisher
New York: Springer US
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Language
English
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New York: Springer US
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Contents
Genotoxic anti-cancer therapies such as chemotherapy and radiotherapy can contribute to an increase in second malignancies in cancer survivors due to their oncogenic effects on non-cancerous cells. Inhibition of histone deacetylase (HDAC) proteins or the proteasome differ from chemotherapy in that they eliminate cancer cells by regulating gene expr...
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Full title
Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent
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TN_cdi_proquest_journals_2210797145
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2210797145
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ISSN
1360-8185
E-ISSN
1573-675X
DOI
10.1007/s10495-019-01543-x
