Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
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Author / Creator
He, Meng , Chaurushiya, Mira S. , Webster, Joshua D. , Kummerfeld, Sarah , Reja, Rohit , Chaudhuri, Subhra , Chen, Ying-Jiun , Modrusan, Zora , Haley, Benjamin , Dugger, Debra L. , Eastham-Anderson, Jeffrey , Lau, Shari , Dey, Anwesha , Caothien, Roger , Roose-Girma, Merone , Newton, Kim and Dixit, Vishva M.
Publisher
United States: American Association for the Advancement of Science
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English
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United States: American Association for the Advancement of Science
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Contents
Malignancies arising from mutation of tumor suppressors have unexplained tissue proclivity. For example, BAP1 encodes awidely expressed deubiquitinase for histone H2A, but germline mutations are predominantly associated with uveal melanomas and mesotheliomas. We show that BAP1 inactivation causes apoptosis in mouse embryonic stem cells, fibroblasts...
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Full title
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
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TN_cdi_proquest_journals_2211359893
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2211359893
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aav4902
