PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components
PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components
About this item
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Author / Creator
Ma, Zhipeng , Zhu, Peipei , Shi, Hui , Guo, Liwei , Zhang, Qinghe , Chen, Yanan , Chen, Shuming , Zhang, Zhe , Peng, Jinrong and Chen, Jun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The genetic compensation response (GCR) has recently been proposed as a possible explanation for the phenotypic discrepancies between gene-knockout and gene-knockdown
1
,
2
; however, the underlying molecular mechanism of the GCR remains uncharacterized. Here, using zebrafish knockdown and knockout models of the
capn3a
and
nid1...
Alternative Titles
Full title
PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components
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Record Identifier
TN_cdi_proquest_journals_2211915924
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2211915924
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1057-y
