FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synov...
FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes
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Author / Creator
Brandstetter, Bernhard , Dalwigk, Karolina , Platzer, Alexander , Niederreiter, Birgit , Kartnig, Felix , Fischer, Anita , Vladimer, Gregory I. , Byrne, Ruth A. , Sevelda, Florian , Holinka, Johannes , Pap, Thomas , Steiner, Günter , Superti-Furga, Giulio , Smolen, Josef S. , Kiener, Hans P. and Karonitsch, Thomas
Publisher
New York: Elsevier Inc
Journal title
Language
English
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Publisher
New York: Elsevier Inc
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Contents
Fibroblast-like synoviocytes (FLS) are major contributors to joint inflammation in rheumatoid arthritis (RA). Forkhead box O 3 (FOXO3) perturbations in immune cells are increasingly linked to RA pathogenesis. Here, we show that FOXO3 is distinctly inactivated/phosphorylated in the FLS of rheumatoid synovitis. In vitro, stimulation of FLS with tumor...
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Full title
FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes
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TN_cdi_proquest_journals_2213908122
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2213908122
Other Identifiers
ISSN
0023-6837
E-ISSN
1530-0307
DOI
10.1038/s41374-018-0184-7
