MRGPRX4 is a novel bile acid receptor in cholestatic itch
MRGPRX4 is a novel bile acid receptor in cholestatic itch
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Author / Creator
Yu, Huasheng , Zhao, Tianjun , Liu, Simin , Wu, Qinxue , Johnson, Omar , Wu, Zhaofa , Zhuang, Zihao , Shi, Yaocheng , He, Renxi , Yang, Yong , Sun, Jianjun , Wang, Xiaoqun , Xu, Haifeng , Zeng, Zheng , Lei, Xiaoguang , Luo, Wenqin and Li, Yulong
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Patients with liver diseases often suffer from chronic itch or pruritus, yet the itch-causing pruritogen(s) and their cognate receptor(s) remain largely elusive. Using transcriptomics and GPCR activation assays, we found that an orphan, primate specific MRGPRX4 is expressed in human dorsal root ganglia (hDRG) and selectively activated by bile acids...
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Full title
MRGPRX4 is a novel bile acid receptor in cholestatic itch
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TN_cdi_proquest_journals_2222334869
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2222334869
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E-ISSN
2692-8205
DOI
10.1101/633446
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https://www.proquest.com/docview/2222334869?pq-origsite=primo&accountid=13902
