The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pin1 interacts with Notch1 to increases its cleavage by γ-secretase and thus its transcriptional activity. In a feedback loop, Notch1 controls Pin1 expression, which results in enhanced Notch1 tumorigenic activity.
Signalling through Notch receptors requires ligand-induced cleavage to release the intracellular domain, which acts as a transcripti...
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Full title
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
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TN_cdi_proquest_journals_222269467
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222269467
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1822
