Presenilin-1 differentially facilitates endoproteolysis of the [beta]-amyloid precursor protein and...
Presenilin-1 differentially facilitates endoproteolysis of the [beta]-amyloid precursor protein and Notch
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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Mutations in the presenilin-1 (PS1) gene are associated with Alzheimer's disease and cause increased secretion of the neurotoxic amyloid-beta peptide (Abeta). Critical intramembraneous aspartates at residues 257 and 385 are required for the function of PS1 protein. Here we investigate the biological function of a naturally occurring PS1 splice vari...
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Full title
Presenilin-1 differentially facilitates endoproteolysis of the [beta]-amyloid precursor protein and Notch
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TN_cdi_proquest_journals_222278798
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222278798
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/35008626
