Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Min...
Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation
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Publisher
Boston: Springer US
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Language
English
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Publisher
Boston: Springer US
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ABSTRACT
Purpose
Nonlinear oral absorption due to poor solubility often impedes drug development. The purpose of this study was to elucidate the rate-limiting process in oral absorption of Biopharmaceutical Classification System (BCS) class II (low solubility–high permeability) drugs in order to predict nonlinear absorption of dose caused by...
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Full title
Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation
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TN_cdi_proquest_journals_222668936
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222668936
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ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-008-9637-9
