Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer microenvironments, and subsequent signaling through the MET receptor is involved in cancer progression. However, the structure of HGF remains elusive, and few small/medium-sized molecules can modulate HGF. Here, we identified HiP-8, a macrocyclic peptide c...
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Full title
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
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TN_cdi_proquest_journals_2226767683
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2226767683
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ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0285-7
