Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles
Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles
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Ishihara, Tsutomu , Takeda, Miho , Sakamoto, Haruka , Kimoto, Ayumi , Kobayashi, Chisa , Takasaki, Naoko , Yuki, Kanae , Tanaka, Ken-ichiro , Takenaga, Mitsuko , Igarashi, Rie , Maeda, Taishi , Yamakawa, Naoki , Okamoto, Yoshinari , Otsuka, Masami , Ishida, Tatsuhiro , Kiwada, Hiroshi , Mizushima, Yutaka and Mizushima, Tohru
Publisher
Boston: Boston : Springer US
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English
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Boston: Boston : Springer US
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Purpose We recently developed prostaglandin E₁ (PGE₁)-encapsulated nanoparticles, prepared with a poly(lactide) homopolymer (PLA, Mw = 17,500) and monomethoxy poly(ethyleneglycol)-PLA block copolymer (PEG-PLA) (NP-L20). In this study, we tested whether the accelerated blood clearance (ABC) phenomenon is observed with NP-L20 and other PEG-modified P...
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Full title
Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles
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Record Identifier
TN_cdi_proquest_journals_222701433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222701433
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ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-009-9943-x
