Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates
Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates
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Publisher
Boston: Springer US
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Language
English
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Publisher
Boston: Springer US
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Purpose
Recently, it was reported that the apparent Michaelis-Menten constant (Km
(app)
) of a P-glycoprotein (P-gp) substrate, defined for the extracellular substrate concentration, increases as the P-gp expression level in the cell increases. By its nature, the Km value should not depend on the level of P-gp expression. The purpose of th...
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Full title
Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates
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TN_cdi_proquest_journals_222725786
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222725786
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ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-009-0026-9
