Defective survival of naive CD8+ T lymphocytes in the absence of the [beta]3 regulatory subunit of v...
Defective survival of naive CD8+ T lymphocytes in the absence of the [beta]3 regulatory subunit of voltage-gated calcium channels
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New York: Nature Publishing Group
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Language
English
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Publisher
New York: Nature Publishing Group
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The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of naive CD8(+) T cells. Deficiency...
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Full title
Defective survival of naive CD8+ T lymphocytes in the absence of the [beta]3 regulatory subunit of voltage-gated calcium channels
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TN_cdi_proquest_journals_222733549
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222733549
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.1793
