Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynami...
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I
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Cham: Springer International Publishing
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English
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Cham: Springer International Publishing
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The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant drugs used for the prevention of organ rejection following transplantation. Both agents are metabolic substrates for cytochrome P450 (CYP) 3A enzymes — in particular, CYP3A4 and CYP3A5 — and are transported out of cells via P-glycoprotein (ABCB1). Several sin...
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Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I
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TN_cdi_proquest_journals_222744370
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222744370
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ISSN
0312-5963
E-ISSN
1179-1926
DOI
10.2165/11317350-000000000-00000
