Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death
Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Chemotherapy often leads to premature death of oocytes, and thus infertility, in young individuals with cancer. Here, Stefania Gonfloni and her colleagues show that chemotherapy-induced activation of the kinase c-Abl is responsible for this oocyte failure and that,
in vivo
, the c-Abl inhibitor imatinib prevents this effect (
pages 1124–11...
Alternative Titles
Full title
Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_223111655
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223111655
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2033
