Identification of the major A[beta]1-42-degrading catabolic pathway in brain parenchyma: Suppression...
Identification of the major A[beta]1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
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New York: Nature Publishing Group
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English
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New York: Nature Publishing Group
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Alzheimer amyloid beta-peptide (Abeta) is a physiological peptide constantly anabolized and catabolized under normal conditions. We investigated the mechanism of catabolism by tracing multiple-radiolabeled synthetic peptide injected into rat hippocampus. The Abeta1-42 peptide underwent full degradation through limited proteolysis conducted by neutr...
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Identification of the major A[beta]1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
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TN_cdi_proquest_journals_223125533
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223125533
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1078-8956
E-ISSN
1546-170X
DOI
10.1038/72237
