Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1
Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1
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Author / Creator
Yin, Qi , Wang, Hongye , Xie, Zhenfei , Jin, Lifan , Ding, Yifu , Li, Na , Li, Yan , Wang, Qiong , Liu, Xinyi , Wang, Kai , Xu, Liuqing , Cheng, Yanbo , Boran Chang , Zhong, Cuiqing , Yu, Qian , Tang, Wei , Yang, Wenjun , Zhang, Fan , Chen, Ding , Bao, Lan , Zhou, Bin , Hu, Ping and Li, Jinsong
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Multisystem manifestations in myotonic dystrophy type 1 (DM1) may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK, including Dmpk and its neighboring genes (Six5 or Dmwd) and downstream Mbnl1. However, the direct evidences are lack. Here, we develop a new strategy to generate mice carrying multigene...
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Full title
Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1
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TN_cdi_proquest_journals_2234284921
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2234284921
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E-ISSN
2692-8205
DOI
10.1101/658526
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https://www.proquest.com/docview/2234284921?pq-origsite=primo&accountid=13902
