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The Use of iPSC-Derived Cardiomyocytes and Optical Mapping for Erythromycin Arrhythmogenicity Testin...

The Use of iPSC-Derived Cardiomyocytes and Optical Mapping for Erythromycin Arrhythmogenicity Testin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2235406098

The Use of iPSC-Derived Cardiomyocytes and Optical Mapping for Erythromycin Arrhythmogenicity Testing

About this item

Full title

The Use of iPSC-Derived Cardiomyocytes and Optical Mapping for Erythromycin Arrhythmogenicity Testing

Publisher

New York: Springer US

Journal title

Cardiovascular toxicology, 2019-12, Vol.19 (6), p.518-528

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (
I
Kr
) without affecting either the slow delayed rectifying potassium current (
I
Ks
) or inward rectifying potassium current (
I
K1
). Erythromycin exerts this effec...

Alternative Titles

Full title

The Use of iPSC-Derived Cardiomyocytes and Optical Mapping for Erythromycin Arrhythmogenicity Testing

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2235406098

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2235406098

Other Identifiers

ISSN

1530-7905

E-ISSN

1559-0259

DOI

10.1007/s12012-019-09532-x

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