Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
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Author / Creator
Lee, Yongchan , Wiriyasermkul, Pattama , Jin, Chunhuan , Quan, Lili , Ohgaki, Ryuichi , Okuda, Suguru , Kusakizako, Tsukasa , Nishizawa, Tomohiro , Oda, Kazumasa , Ishitani, Ryuichiro , Yokoyama, Takeshi , Nakane, Takanori , Shirouzu, Mikako , Endou, Hitoshi , Nagamori, Shushi , Kanai, Yoshikatsu and Nureki, Osamu
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a disulfide-linked heterodimer with CD98 heavy chain (CD98hc, 4F2hc or SLC3A2), but the mechanism of assembly and amino acid transport are poorly understood. Here we report...
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Full title
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
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TN_cdi_proquest_journals_2235647091
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2235647091
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-019-0237-7
