Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
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Publisher
Waltham, MA: Massachusetts Medical Society
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Language
English
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Publisher
Waltham, MA: Massachusetts Medical Society
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Contents
Inhibition of poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP), a key enzyme for the repair of breaks in DNA, can lead to the accumulation of breaks in double-stranded DNA. The BRCA1 and BRCA2 proteins help to repair such breaks. In this phase 1 trial, the PARP inhibitor olaparib was shown to lack the severe toxic effects of conventional...
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Full title
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
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TN_cdi_proquest_journals_223909938
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223909938
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa0900212
