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A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223924980

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

About this item

Full title

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

Publisher

Boston, MA: Massachusetts Medical Society

Journal title

The New England journal of medicine, 2008-05, Vol.358 (22), p.2344-2354

Language

English

Formats

Publication information

Publisher

Boston, MA: Massachusetts Medical Society

More information

Scope and Contents

Contents

In this 12-week randomized trial, prucalopride, a selective 5-HT
4
receptor agonist, substantially relieved constipation. Because of cardiac adverse events seen with other 5-HT
4
receptor agonists, electrocardiograms were monitored; there was no prolongation of the corrected QT interval. Diarrhea and headache were more common in the pru...

Alternative Titles

Full title

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_223924980

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223924980

Other Identifiers

ISSN

0028-4793

E-ISSN

1533-4406

DOI

10.1056/NEJMoa0800670

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