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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hyperte...

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hyperte...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2248017939

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

About this item

Full title

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence-associated se...

Alternative Titles

Full title

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2248017939

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2248017939

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/684811