Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance
Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance
About this item
Full title
Author / Creator
Tacconi, Eliana MC , Badie, Sophie , De Gregoriis, Giuliana , Reisländer, Timo , Lai, Xianning , Porru, Manuela , Folio, Cecilia , Moore, John , Kopp, Arnaud , Baguña Torres, Júlia , Sneddon, Deborah , Green, Marcus , Dedic, Simon , Lee, Jonathan W , Batra, Ankita Sati , Rueda, Oscar M , Bruna, Alejandra , Leonetti, Carlo , Caldas, Carlos , Cornelissen, Bart , Brino, Laurent , Ryan, Anderson , Biroccio, Annamaria and Tarsounas, Madalena
Publisher
Frankfurt: EMBO Press
Journal title
Language
English
Formats
Publication information
Publisher
Frankfurt: EMBO Press
Subjects
More information
Scope and Contents
Contents
Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2‐deficient cells, we screened a chemical library containing compounds in clinical use. The top hit was chlorambucil, a bifunctiona...
Alternative Titles
Full title
Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance
Authors, Artists and Contributors
Author / Creator
Badie, Sophie
De Gregoriis, Giuliana
Reisländer, Timo
Lai, Xianning
Porru, Manuela
Folio, Cecilia
Moore, John
Kopp, Arnaud
Baguña Torres, Júlia
Sneddon, Deborah
Green, Marcus
Dedic, Simon
Lee, Jonathan W
Batra, Ankita Sati
Rueda, Oscar M
Bruna, Alejandra
Leonetti, Carlo
Caldas, Carlos
Cornelissen, Bart
Brino, Laurent
Ryan, Anderson
Biroccio, Annamaria
Tarsounas, Madalena
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2251963637
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2251963637
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201809982
