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Detailed Regulatory Interaction Map of the Human Heart Facilitates Gene Discovery for Cardiovascular...

Detailed Regulatory Interaction Map of the Human Heart Facilitates Gene Discovery for Cardiovascular...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2259096174

Detailed Regulatory Interaction Map of the Human Heart Facilitates Gene Discovery for Cardiovascular Disease

About this item

Full title

Detailed Regulatory Interaction Map of the Human Heart Facilitates Gene Discovery for Cardiovascular Disease

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-07

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Most disease-associated variants identified by population based genetic studies are non-coding, which compromises finding causative genes and mechanisms. Presumably they interact through looping with nearby genes to modulate transcription. Hi-C provides the most complete and unbiased method for genome-wide identification of potential regulatory int...

Alternative Titles

Full title

Detailed Regulatory Interaction Map of the Human Heart Facilitates Gene Discovery for Cardiovascular Disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2259096174

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2259096174

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/705715