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HOTAIR promotes an epithelial-to-mesenchymal transition through relocation of the histone demethylas...

HOTAIR promotes an epithelial-to-mesenchymal transition through relocation of the histone demethylas...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2268460895

HOTAIR promotes an epithelial-to-mesenchymal transition through relocation of the histone demethylase Lsd1

About this item

Full title

HOTAIR promotes an epithelial-to-mesenchymal transition through relocation of the histone demethylase Lsd1

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-08

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Epithelial-to-mesenchymal transition (EMT) drives a loss of epithelial traits by neoplastic cells enabling metastasis and recurrence in cancer. HOTAIR emerged as one of the most renowned long noncoding RNAs promoting EMT mostly as a scaffold for PRC2 and repressive histone H3 Lys27 methylation at gene promoters. In addition to PRC2, HOTAIR interact...

Alternative Titles

Full title

HOTAIR promotes an epithelial-to-mesenchymal transition through relocation of the histone demethylase Lsd1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2268460895

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2268460895

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/724948