IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibrob...
IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein–specific PET/CT
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Full title
Author / Creator
Röhrich, Manuel , Loktev, Anastasia , Wefers, Annika K. , Altmann, Annette , Paech, Daniel , Adeberg, Sebastian , Windisch, Paul , Hielscher, Thomas , Flechsig, Paul , Floca, Ralf , Leitz, Dominik , Schuster, Julius P. , Huber, Peter E. , Debus, Jürgen , von Deimling, Andreas , Lindner, Thomas and Haberkorn, Uwe
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Purpose
Targeting fibroblast activation protein (FAP) is a new diagnostic approach allowing the visualization of tumor stroma. Here, we applied FAP-specific PET imaging to gliomas. We analyzed the target affinity and specificity of two FAP ligands (FAPI-02 and FAPI-04) in vitro, and the pharmacokinetics and biodistribution in mice in vivo. Clini...
Alternative Titles
Full title
IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein–specific PET/CT
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_journals_2268837047
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2268837047
Other Identifiers
ISSN
1619-7070
E-ISSN
1619-7089
DOI
10.1007/s00259-019-04444-y
