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WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2270277281

WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

About this item

Full title

WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-08

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The cohesin complex plays essential roles in sister chromatin cohesin, chromosome organization and gene expression. The role of cohesin in gene regulation is incompletely understood. Here, we report that the cohesin release factor WAPL is crucial for maintaining a pool of dynamic cohesin bound to regions that are associated with lineage specific ge...

Alternative Titles

Full title

WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2270277281

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2270277281

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/731141