The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells...
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-xL protein
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The broad-range cyclin-dependent kinase inhibitor 7-hydroxystaurosporine (UCN-01) is known to induce both a G1 cell cycle arrest and apoptosis. The mechanism of UCN-01-induced apoptosis is largely unknown. We analysed the mechanism of cytotoxicity of UCN-01 in four established colon carcinoma cell lines. The cell lines SW48 and LS513 responded to U...
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The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-xL protein
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TN_cdi_proquest_journals_227352264
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_227352264
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0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1207842
