PKC[theta] mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
PKC[theta] mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
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New York: Nature Publishing Group
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English
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New York: Nature Publishing Group
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Protein kinase (PK)C theta is a critical regulator of mature T-cell activation and proliferation, being implicated in TCR-triggered nuclear factor (NF)-kappa B activation and providing important survival signals to leukemic T cells. We previously showed that overexpression of pT alpha/pre-TCR and constitutive activation of NF-kappa B characterize t...
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PKC[theta] mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
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TN_cdi_proquest_journals_227358211
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_227358211
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1208302
