Nutrient regulation of the islet epigenome controls adaptive insulin secretion
Nutrient regulation of the islet epigenome controls adaptive insulin secretion
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Author / Creator
Wortham, Matthew , Liu, Fenfen , Fleischman, Johanna Y , Wallace, Martina , Mulas, Francesca , Vinckier, Nicholas K , Harrington, Austin R , Cross, Benjamin R , Chiou, Joshua , Patel, Nisha A , Sui, Yinghui , Jhala, Ulupi S , Shirihai, Orian S , Huising, Mark O , Gaulton, Kyle J , Metallo, Christian M and Sander, Maike
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient-stimulated histone acetylation plays a key role in adapting insulin secretion through regulation of genes involved in β-cell nutrient s...
Alternative Titles
Full title
Nutrient regulation of the islet epigenome controls adaptive insulin secretion
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TN_cdi_proquest_journals_2277171732
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2277171732
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/742403
How to access this item
https://www.proquest.com/docview/2277171732?pq-origsite=primo&accountid=13902
