Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells thr...
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The involvement of mammalian target of rapamycin (mTOR) in the positive regulation of oncogenesis has been well documented and thus mTOR has emerged as an attractive cancer therapeutic target. Although rapamycin and its analogues (rapalogs) are FDA-approved for the treatment of certain cancers, major success in targeting mTOR, particularly with new...
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Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation
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TN_cdi_proquest_journals_2281925823
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2281925823
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0950-9232
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1476-5594
DOI
10.1038/s41388-019-0877-4
