Insights into antifolate resistance from malarial DHFR-TS structures
Insights into antifolate resistance from malarial DHFR-TS structures
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Plasmodium falciparum
dihydrofolate reductase–thymidylate synthase (PfDHFR-TS) is an important target of antimalarial drugs. The efficacy of this class of DHFR-inhibitor drugs is now compromised because of mutations that prevent drug binding yet retain enzyme activity. The crystal structures of PfDHFR-TS from the wild type (TM4/8.2) and the quad...
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Full title
Insights into antifolate resistance from malarial DHFR-TS structures
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TN_cdi_proquest_journals_228280226
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_228280226
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsb921
