The ternary complex of antithrombin–anhydrothrombin–heparin reveals the basis of inhibitor specifici...
The ternary complex of antithrombin–anhydrothrombin–heparin reveals the basis of inhibitor specificity
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Antithrombin, the principal physiological inhibitor of the blood coagulation proteinase thrombin, requires heparin as a cofactor. We report the crystal structure of the rate-determining encounter complex formed between antithrombin, anhydrothrombin and an optimal synthetic 16-mer oligosaccharide. The antithrombin reactive center loop projects from...
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The ternary complex of antithrombin–anhydrothrombin–heparin reveals the basis of inhibitor specificity
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TN_cdi_proquest_journals_228342966
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_228342966
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ISSN
1545-9993
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1545-9985
DOI
10.1038/nsmb810
