Somatic cancer mutations in the MLL 1 histone methyltransferase modulate its enzymatic activity and...
Somatic cancer mutations in the MLL 1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR 5/ RBBP 5/ ASH 2L complex
About this item
Full title
Author / Creator
Publisher
Hoboken: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
Hoboken: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Somatic missense mutations in the mixed lineage leukemia 1 (
MLL
1) histone H3K4 methyltransferase are often observed in cancers.
MLL
1 forms a complex with
WDR
5,
RBBP
5, and
ASH
2L (
WRA
) which stimulates its activity. The
MM
‐102 compound prevents the interaction between
MLL
1 and
WDR
5 and...
Alternative Titles
Full title
Somatic cancer mutations in the MLL 1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR 5/ RBBP 5/ ASH 2L complex
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2290191860
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2290191860
Other Identifiers
ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.12041
