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Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basa...

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basa...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2290618143

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

About this item

Full title

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-09

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) proved an efficient medical therapy of BCC, although lack of durable responses and frequent development of drug resistance pose major challenges to anti...

Alternative Titles

Full title

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2290618143

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2290618143

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/768796