Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basa...
Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) proved an efficient medical therapy of BCC, although lack of durable responses and frequent development of drug resistance pose major challenges to anti...
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Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity
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TN_cdi_proquest_journals_2290618143
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2290618143
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2692-8205
DOI
10.1101/768796
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https://www.proquest.com/docview/2290618143?pq-origsite=primo&accountid=13902