p63 is a cereblon substrate involved in thalidomide teratogenicity
p63 is a cereblon substrate involved in thalidomide teratogenicity
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic and antimyeloma activities. CRBN functions as a substrate receptor of the E3 ubiquitin ligase CRL4, whose substrate specificity is modulated by thalidomide and its analogs. Although a number of CRL4
CRBN
substrates ha...
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Full title
p63 is a cereblon substrate involved in thalidomide teratogenicity
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TN_cdi_proquest_journals_2307386338
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2307386338
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0366-7
