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Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-li...

Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-li...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2308330797

Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-like condensates in muscle cells

About this item

Full title

Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-like condensates in muscle cells

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-10

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Fragile-X mental retardation autosomal homolog-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple protein isoforms and mis-splicing has been implicate...

Alternative Titles

Full title

Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-like condensates in muscle cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2308330797

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2308330797

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/818476