PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Retinitis pigmentosa (RP) is a neurodegenerative disorder that causes irreversible vision loss in over 1.5 million individuals world-wide. In this study, we demonstrate that a metabolic reprogramming can treat degeneration in a Pde6β preclinical model of RP. Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that transfers phosphate from phosphoenolp...
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Full title
PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
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TN_cdi_proquest_journals_2310816481
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2310816481
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E-ISSN
2692-8205
DOI
10.1101/826651
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https://www.proquest.com/docview/2310816481?pq-origsite=primo&accountid=13902
