Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import
Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import
About this item
Full title
Author / Creator
Badgley, Michael A , Kremer, Daniel , Maurer, H Carlo , Delgiorno, Kathleen E , Ho-Joon, Lee , Purohit, Vinee , Sagalovskiy, Irina , Ma, Alice , Kapillian, Jonathan , Firl, Christina Em , Decker, Amanda R , Sastra, Steve A , Palermo, Carmine F , Andrade, Leonardo R , Sajjakulnukit, Peter , Zhang, Li , Tolstyka, Zachary P , Hirschhorn, Tal , Lamb, Candice , Liu, Tong , Gu, Wei , Seeley, E Scott , Stone, Everett , Georgiou, George , Manor, Uri , Iuga, Alina , Wahl, Geoffrey M , Stockwell, Brent R , Lyssiotis, Costas A and Olive, Kenneth P
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma (PDA) is the third-leading cause of cancer mortality in the US and is highly resistant to classical, targeted, and immune therapies. We show that human PDA cells are dependent on the provision of exogenous cystine to avert a catastrophic accumulation of lipid reactive oxygen species (ROS) that, left unchecked, leads...
Alternative Titles
Full title
Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import
Authors, Artists and Contributors
Author / Creator
Kremer, Daniel
Maurer, H Carlo
Delgiorno, Kathleen E
Ho-Joon, Lee
Purohit, Vinee
Sagalovskiy, Irina
Ma, Alice
Kapillian, Jonathan
Firl, Christina Em
Decker, Amanda R
Sastra, Steve A
Palermo, Carmine F
Andrade, Leonardo R
Sajjakulnukit, Peter
Zhang, Li
Tolstyka, Zachary P
Hirschhorn, Tal
Lamb, Candice
Liu, Tong
Gu, Wei
Seeley, E Scott
Stone, Everett
Georgiou, George
Manor, Uri
Iuga, Alina
Wahl, Geoffrey M
Stockwell, Brent R
Lyssiotis, Costas A
Olive, Kenneth P
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2311132487
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2311132487
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/827972
How to access this item
https://www.proquest.com/docview/2311132487?pq-origsite=primo&accountid=13902
