The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into th...
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
About this item
Full title
Author / Creator
Ramos-Rodríguez, Mireia , Raurell-Vila, Helena , Colli, Maikel L. , Alvelos, Maria Inês , Subirana-Granés, Marc , Juan-Mateu, Jonàs , Norris, Richard , Turatsinze, Jean-Valery , Nakayasu, Ernesto S. , Webb-Robertson, Bobbie-Jo M. , Inshaw, Jamie R. J. , Marchetti, Piero , Piemonti, Lorenzo , Esteller, Manel , Todd, John A. , Metz, Thomas O. , Eizirik, Décio L. and Pasquali, Lorenzo
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the β-cell regulatory landscape. We expand the repertoire of human islet regulatory elements by mapping stim...
Alternative Titles
Full title
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Authors, Artists and Contributors
Author / Creator
Raurell-Vila, Helena
Colli, Maikel L.
Alvelos, Maria Inês
Subirana-Granés, Marc
Juan-Mateu, Jonàs
Norris, Richard
Turatsinze, Jean-Valery
Nakayasu, Ernesto S.
Webb-Robertson, Bobbie-Jo M.
Inshaw, Jamie R. J.
Marchetti, Piero
Piemonti, Lorenzo
Esteller, Manel
Todd, John A.
Metz, Thomas O.
Eizirik, Décio L.
Pasquali, Lorenzo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2313533192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2313533192
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0524-6
