Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the...
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery
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Author / Creator
Wu, Nan , Yuan, Zhidong , Du, Kevin Y. , Fang, Ling , Lyu, Juanjuan , Zhang, Chao , He, Alina , Eshaghi, Esra , Zeng, Kaixuan , Ma, Jian , Du, William W. and Yang, Burton B.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Yap is the key component of Hippo pathway which plays crucial roles in tumorigenesis. Inhibition of Yap activity could promote apoptosis, suppress proliferation, and restrain metastasis of cancer cells. However, how Yap is regulated is not fully understood. Here, we reported Yap being negatively regulated by its circular RNA (circYap) through the s...
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Full title
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery
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TN_cdi_proquest_journals_2314312346
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2314312346
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ISSN
1350-9047,1476-5403
E-ISSN
1476-5403
DOI
10.1038/s41418-019-0337-2
