Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regressio...
Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Purpose: Rhabdoid tumor is a pediatric cancer characterized by the biallelic inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. SMARCB1 inactivation leads to SWI/SNF redistribution to favor a proliferative dedifferentiated cellular state. Although this deletion is the known oncogenic driver, SWI/SNF therapeutic targetin...
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Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor
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TN_cdi_proquest_journals_2320955468
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2320955468
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E-ISSN
2692-8205
DOI
10.1101/861484
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https://www.proquest.com/docview/2320955468?pq-origsite=primo&accountid=13902
