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Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate e...

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate e...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2334562134

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes

About this item

Full title

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The genomes of RNA and small DNA viruses of vertebrates display significant suppression of CpG dinucleotide frequencies. Artificially increasing dinucleotide frequencies results in substantial attenuation of virus replication, suggesting that these compositional changes may facilitate recognition of non-self RNA sequences. Recently, the interferon...

Alternative Titles

Full title

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2334562134

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2334562134

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.01.07.897132