Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitme...
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Most G protein-coupled receptors (GPCRs) recruit β-arrestins and are internalized upon agonist stimulation. For the μ-opioid receptor (μ-OR), this process has been linked to development of opioid tolerance. GPCR kinases (GRKs), particularly GRK2 and GRK3, have been shown to be important for μ-OR recruitment of β-arrestin and internalization. Howeve...
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Full title
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
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TN_cdi_proquest_journals_2334873927
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2334873927
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E-ISSN
2692-8205
DOI
10.1101/2020.01.08.898338
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https://www.proquest.com/docview/2334873927?pq-origsite=primo&accountid=13902
