Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal canc...
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Drug resistance is a major problem limiting the efficacy of chemotherapy in cancer treatment, and the hypoxia-induced stabilization of HIF-1α plays a role in this process. HIF-1α overexpression has been observed in a variety of human cancers, including colorectal cancer (CRC). Therefore, targeting HIF-1α is a promising strategy for overcoming chemo...
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Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
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TN_cdi_proquest_journals_2342391512
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2342391512
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-019-0999-8
