Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis
Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis
About this item
Full title
Author / Creator
Li, Bin , Chen, Yuyuan , Wang, Fei , Guo, Jun , Fu, Wen , Li, Min , Zheng, Qichang , Liu, Yong , Fan, Lingling , Li, Lei and Xu, Chuanrui
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Bmi1 is overexpressed in one-third of hepatocellular carcinoma (HCC) patients and acts as an oncogene in hepatocarcinogenesis. However, the underlying mechanism is unclear. The role of TGFβ signalling in HCC is not well defined as well. Here, we report that TGFβ2 is a target of Bmi1 in HCC and has a tumour-suppressing role. In Bmi1-knockout mouse l...
Alternative Titles
Full title
Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2348281531
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2348281531
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-019-1043-8
