Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-d...
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain
About this item
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Author / Creator
Alic, Ivan , Goh, Pollyanna A , Murray, Aoife , Portelius, Erik , Gkanatsiou, Eleni , Gough, Gillian , Mok, Kin Y , Koschut, David , Brunmeir, Reinhard , Yeap, Yie Jie , O'brien, Niamh L , Groet, Jurgen , Shao, Xiaowei , Havlicek, Steven , Dunn, Norris R , Kvartsberg, Hlin , Brinkmalm, Gunnar , Hithersay, Rosalyn , Startin, Carla , Hamburg, Sarah , Phillips, Margaret , Pervushin, Konstantin , Turmaine, Mark , Wallon, David , Rovelet-Lecrux, Anne , Soininen, Hilkka , Volpi, Emanuela , Martin, Joanne E , Jia Nee Foo , Becker, David L , Rostagno, Agueda , Ghiso, Jorge , Krsnik, Zeljka , Simic, Goran , Kostovic, Ivica , Mitrecic, Dinko , Consortium, Londowns , Francis, Paul T , Blennow, Kaj , Strydom, Andre , Hardy, John , Zetterberg, Henrik and Nizetic, Dean
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
A population of >6 million people worldwide at high risk of Alzheimer's disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-protein gene. We report AD-like pathology in cerebral organoids grown in vitro from non-invasively sampl...
Alternative Titles
Full title
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain
Authors, Artists and Contributors
Author / Creator
Goh, Pollyanna A
Murray, Aoife
Portelius, Erik
Gkanatsiou, Eleni
Gough, Gillian
Mok, Kin Y
Koschut, David
Brunmeir, Reinhard
Yeap, Yie Jie
O'brien, Niamh L
Groet, Jurgen
Shao, Xiaowei
Havlicek, Steven
Dunn, Norris R
Kvartsberg, Hlin
Brinkmalm, Gunnar
Hithersay, Rosalyn
Startin, Carla
Hamburg, Sarah
Phillips, Margaret
Pervushin, Konstantin
Turmaine, Mark
Wallon, David
Rovelet-Lecrux, Anne
Soininen, Hilkka
Volpi, Emanuela
Martin, Joanne E
Jia Nee Foo
Becker, David L
Rostagno, Agueda
Ghiso, Jorge
Krsnik, Zeljka
Simic, Goran
Kostovic, Ivica
Mitrecic, Dinko
Consortium, Londowns
Francis, Paul T
Blennow, Kaj
Strydom, Andre
Hardy, John
Zetterberg, Henrik
Nizetic, Dean
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2349081580
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2349081580
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.01.29.918037
How to access this item
https://www.proquest.com/docview/2349081580?pq-origsite=primo&accountid=13902
