Promoter CpG density predicts downstream gene loss-of-function intolerance
Promoter CpG density predicts downstream gene loss-of-function intolerance
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract The aggregation and joint analysis of large numbers of exome sequences has recently made it possible to de-rive estimates of intolerance to loss-of-function (LoF) variation for human genes. Here, we demonstrate strong and widespread coupling between genic LoF-intolerance and promoter CpG density across the human genome. Genes downstream of...
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Promoter CpG density predicts downstream gene loss-of-function intolerance
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TN_cdi_proquest_journals_2355765981
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2355765981
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E-ISSN
2692-8205
DOI
10.1101/2020.02.15.936351
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https://www.proquest.com/docview/2355765981?pq-origsite=primo&accountid=13902
