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Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostas...

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostas...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2357122256

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

About this item

Full title

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Abstract Chronic kidney disease (CKD) remains a major epidemiological, clinical and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) suffer a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney fibrosis and contributes to its pathogenesis. To d...

Alternative Titles

Full title

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2357122256

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2357122256

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.02.18.952440