Quantitative dialing of gene expression via precision targeting of KRAB repressor
Quantitative dialing of gene expression via precision targeting of KRAB repressor
About this item
Full title
Author / Creator
Wilken, Matthew S , Ciarlo, Christie , Pearl, Jocelynn , Schanzer, Elaine , Liao, Hanna , Benjamin Van Biber , Queitsch, Konstantin , Bloom, Jordan , Federation, Alexander , Acosta, Reyes , Vong, Shinny , Otterman, Ericka , Dunn, Douglass , Wang, Hao , Zrazhevskiy, Pavel , Nandakumar, Vivek , Bates, Daniel , Sandstrom, Richard , Urnov, Fyodor D , Funnell, Alister , Green, Shon and Stamatoyannopoulos, John A
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Abstract Human genes are regulated quantitatively, yet the ability to specify the expression level of a native gene accurately and specifically using a defined reagent has remained elusive. Here we show that precise targeting of KRAB repressive domain within regulatory DNA unlocks an endogenous quantitative ‘dial’ that can be engaged at nucleotide...
Alternative Titles
Full title
Quantitative dialing of gene expression via precision targeting of KRAB repressor
Authors, Artists and Contributors
Author / Creator
Ciarlo, Christie
Pearl, Jocelynn
Schanzer, Elaine
Liao, Hanna
Benjamin Van Biber
Queitsch, Konstantin
Bloom, Jordan
Federation, Alexander
Acosta, Reyes
Vong, Shinny
Otterman, Ericka
Dunn, Douglass
Wang, Hao
Zrazhevskiy, Pavel
Nandakumar, Vivek
Bates, Daniel
Sandstrom, Richard
Urnov, Fyodor D
Funnell, Alister
Green, Shon
Stamatoyannopoulos, John A
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2359036465
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2359036465
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.02.19.956730
How to access this item
https://www.proquest.com/docview/2359036465?pq-origsite=primo&accountid=13902
