Ovarian Cancer Risk Variants are Enriched in Histotype-Specific Enhancers that Disrupt Transcription...
Ovarian Cancer Risk Variants are Enriched in Histotype-Specific Enhancers that Disrupt Transcription Factor Binding Sites
About this item
Full title
Author / Creator
Jones, Michelle R , Pei-Chen, Peng , Coetzee, Simon G , Tyrer, Jonathan , Reyes, Alberto Luiz P , Rosario I Corona De La Fuente , Davis, Brian D , Chen, Stephanie , Dezem, Felipe , Ji-Heui Seo , Ovarian Cancer Association Consortium , Berman, Benjamin P , Freedman, Matthew L , Plummer, Jasmine T , Lawrenson, Kate , Pharoah, Paul , Hazelett, Dennis J and Gayther, Simon A
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome wide association studies (GWAS) have identified 39 regions associated with risk of epithelial ovarian cancer (EOC). The vast majority of these variants lie in the non-coding genome, suggesting they mediate thei...
Alternative Titles
Full title
Ovarian Cancer Risk Variants are Enriched in Histotype-Specific Enhancers that Disrupt Transcription Factor Binding Sites
Authors, Artists and Contributors
Author / Creator
Pei-Chen, Peng
Coetzee, Simon G
Tyrer, Jonathan
Reyes, Alberto Luiz P
Rosario I Corona De La Fuente
Davis, Brian D
Chen, Stephanie
Dezem, Felipe
Ji-Heui Seo
Ovarian Cancer Association Consortium
Berman, Benjamin P
Freedman, Matthew L
Plummer, Jasmine T
Lawrenson, Kate
Pharoah, Paul
Hazelett, Dennis J
Gayther, Simon A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2363576783
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2363576783
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.02.21.960468
How to access this item
https://www.proquest.com/docview/2363576783?pq-origsite=primo&accountid=13902
